1、Codexis向Tate&Lyle出售新的食品用酶
2016年12月6日:Codexis宣布与Tate&Lyle签订了一份关于提供食品原料生产专用酶的独家协议。
2、Amyris向Nikkol集团出售50%的股份
2016年12月13日,Amyris公司宣布与Nikkol集团成立化妆品合资公司。Amyris以2000万美元的
价格向Nikkol集团出售其子公司Neassance50%的股权,成立该合资公司。
3、Evolva获得生产甜菊糖的关键专利
2016年12月19日,瑞士一家生物化学公司Evolva宣布获得美国专利申请的准许通知书,并称该
技术为“最经济有效的制造甜菊糖苷的生产方法”。
会议预告
1)2017年3月6日-8日,有机过程的研究和开发,帕萨迪纳,美国;
2)2017年5月16日-18日Informex贸易展览和会议,宾夕法尼亚州费城,美国;
3)2017年7月9日-13日,Biotrans 2017,匈牙利布达佩斯;
最新发表文献摘选:
Enzymes beat chemists in the formation of unnatural bonds.
Ducharme J, Auclair K. Chembiochem. 2016 Dec 27. doi: 10.1002/cbic.201600692. [Epub
ahead of print]
Inversion of substrate stereoselectivity of horse liver alcohol
dehydrogenase by substitutions of Ser-48 and Phe-93.
Kim K, Plapp BV. Chem Biol Interact. 2016 Dec 23. pii: S0009-2797(16)30754-2. doi:
10.1016/j.cbi.2016.12.016. [Epub ahead of print]
Alkaline serine proteases from Helicoverpa armigera: potential
candidates for industrial applications.
Akbar SM, Sharma HC. Arch Insect Biochem Physiol. 2016 Dec 26. doi:
10.1002/arch.21367. [Epub ahead of print]
Highly efficient bioreduction of 2-hydroxyacetophenone to (S)- and (R)-1-
phenyl-1, 2-ethanediol by two substrate tolerance carbonyl reductases
with cofactor regeneration.
Cui ZM, Zhang JD, Fan XJ, Zheng GW, Chang HH, Wei WL. J Biotechnol. 2016 Dec 20. pii:
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The catalytic domain of Penicillium crustosum endoglucanase EGL1 has
cellulose-binding capacity and cellulolytic activity.
Xiong W, Yang JK, Chen FY, Han ZG. Enzyme Microb Technol. 2017 Feb;97:71-81. doi:
10.1016/j.enzmictec.2016.11.007.
Highly regioselective hydroxylation of polydatin, a resveratrol
glucoside, for one-step synthesis of astringin, a piceatannol glucoside,
by P450 BM3.
Le TK, Jang HH, Nguyen HT, Doan TT, Lee GY, Park KD, Ahn T, Joung YH, Kang HS, Yun
CH. Enzyme Microb Technol. 2017 Feb;97:34-42. doi: 10.1016/j.enzmictec.2016.11.003.
Evolutionary drivers of thermoadaptation in enzyme catalysis.
Nguyen V, Wilson C, Hoemberger M, Stiller JB, Agafonov RV, Kutter S, English J,
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Designing selectivity in dirhodium metallopeptide catalysts for protein
modification.
Martin SC, Vohidov F, Wang H, Knudsen S, Marzec AA, Ball ZT. Bioconjug Chem. 2016 Dec
30. doi: 10.1021/acs.bioconjchem.6b00716. [Epub ahead of print]
Structure-guided reprogramming of a hydroxylase to halogenate its small
molecule substrate.
Mitchell AJ, Dunham NP, Bergman JA, Wang B, Zhu Q, Chang WC, Liu X, Boal AK.
Biochemistry. 2016 Dec 28. doi: 10.1021/acs.biochem.6b01173. [Epub ahead of print]
Directed evolution of P450cin for mediated electron transfer.
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Schwaneberg U. Protein Eng Des Sel. 2016 Dec 22. doi: 10.1093/protein/gzw072. [Epub
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Chemoenzymatic Dynamic Kinetic Resolution of Secondary Alcohols using an
Air and Moisture stable Iron Racemization Catalyst.
Bäckvall JE, Gustafson KG, Guðmundsson A, Lewis K. Chemistry. 2016 Dec 22. doi:
10.1002/chem.201605754. [Epub ahead of print]
Intracellular Microreactors as Artificial Organelles to Conduct Multiple
Enzymatic Reactions Simultaneously.
Godoy-Gallardo M, Labay C, Jansman MM, Ek PK, Hosta-Rigau L. Adv Healthc Mater. 2016
Dec 22. doi: 10.1002/adhm.201601190. [Epub ahead of print]
Gene cloning, recombinant expression, purification and characterization
of L-methionine decarboxylase from Streptomyces sp. 590.
Hayashi M, Okada A, Yamamoto K, Okugochi T, Kusaka C, Kudou D, Nemoto M, Inagaki J,
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A Single Amino Acid Mutation Converts (R)-5-Diphosphomevalonate
Decarboxylase into A Kinase.
Motoyama K, Unno H, Hattori A, Takaoka T, Ishikita H, Kawaide H, Yoshimura T, Hemmi
H. J Biol Chem. 2016 Dec 21. pii: jbc.M116.752535. doi: 10.1074/jbc.M116.752535.
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Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene
Replaces the Prolyl Peptide Bond.
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Semi-Rational Engineering of Leucine Dehydrogenase for L-2-Aminobutyric
Acid Production.
Xu JM, Cheng F, Fu FT, Hu HF, Zheng YG. Appl Biochem Biotechnol. 2016 Dec 20. doi:
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Production of 8,11-Dihydroxy and 8-Hydroxy Unsaturated Fatty Acids from
Unsaturated Fatty Acids by Recombinant Escherichia coli Expressing 8,11-
Linoleate Diol Synthase from Penicillium chrysogenum.
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Peroxygenases en route to becoming dream catalysts. What are the
opportunities and challenges?
Wang Y, Lan D, Durrani R, Hollmann F. Curr Opin Chem Biol. 2016 Dec 16;37:1-9. doi:
10.1016/j.cbpa.2016.10.007. [Epub ahead of print] Review.
Enantiocomplementary Synthesis of Ƴ-Nitroketones Using Designed and
Evolved Carboligases.
Garrabou X, Verez R, Hilvert D. J Am Chem Soc. 2016 Dec 22. doi:
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Broad substrate affinity and catalytic diversity of fibrinolytic enzyme
from Pheretima posthumous-Purification and molecular characterization
study.
Verma MK, Pulicherla KK. Int J Biol Macromol. 2017 Feb;95:1011-1021. doi:
10.1016/j.ijbiomac.2016.10.090.
Laccase Activity in CTAB-Based Water-in-Oil Microemulsions.
Azimi M, Nafissi-Varcheh N, Faramarzi MA, Aboofazeli R. Iran J Pharm Res. 2016
Summer;15(3):441-452.
Green synthesis of β-sitostanol esters catalyzed by the versatile
lipase/sterol esterase from Ophiostoma piceae.
Molina-Gutiérrez M, Hakalin NL, Rodríguez-Sanchez L, Prieto A, Martínez MJ. Food
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Chemical biology: A radical change in enzyme catalysis.
Bornscheuer UT. Nature. 2016 Dec 14;540(7633):345-346. doi: 10.1038/540345a. No
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Accessing non-natural reactivity by irradiating nicotinamide-dependent
enzymes with light.
Emmanuel MA, Greenberg NR, Oblinsky DG, Hyster TK. Nature. 2016 Dec 14;540(7633):414-
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Functional Characterization of a Novel Amidase Involved in
Biotransformation of Triclocarban and its Dehalogenated Congeners in
Ochrobactrum sp. TCC-2.
Yun H, Liang B, Qiu J, Zhang L, Zhao Y, Jiang J, Wang A. Environ Sci Technol. 2017
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Eichhornia crassipes: Agro-waster for a novel thermostable laccase
production by Pycnoporus sanguineus SYBC-L1.
Wang Z, Liu J, Ning Y, Liao X, Jia Y. J Biosci Bioeng. 2016 Dec 7. pii: S1389-1723(16)
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Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin
Biosynthesis.
Fiers WD, Dodge GJ, Sherman DH, Smith JL, Aldrich CC. J Am Chem Soc. 2016 Dec 14;138
(49):16024-16036.